耐药性妊娠滋养细胞肿瘤相关发病机制和治疗的研究进展

张庆华 杨冰

yL23411永利官网登录附属医院

摘要：妊娠滋养细胞肿瘤（GTN）是一组来源于胎盘滋养细胞异常增殖的恶性肿瘤，可继发于葡萄胎妊娠，也可继发于足月妊娠、早产、异位妊娠或流产。尽管GTN对化疗高度敏感，但化疗药物耐药后的处理是困扰妊娠滋养细胞肿瘤治疗的主要因素。研究表明，在GTN中，低危及高危患者对一线化疗的耐药发生率分别为10%～20%和20%～30%^[1]。因此，本文将对耐药性妊娠滋养细胞肿瘤的发生机制和治疗做一综述，以期对妊娠滋养细胞肿瘤有更全面深入了解认识，为耐药妊娠滋养细胞肿瘤治疗方案的选择提供新的思路。

关键词：妊娠滋养细胞肿瘤;化学治疗;耐药;

Advances on relevant pathogenesis and treatment of drug-resistant gestational trophoblastic neoplasm^①

ZHANG Qinghua,YANG Bing^②.(The Affiliated Hospital of Guilin Medical University,Guilin 541001,China)

Abstract: Gestational trophoblastic neoplasm(GTN)is a group of malignant tumors derived from abnormal proliferation of placental trophoblastic cells, which can be secondary to hydatidiform mole pregnancy, also secondary to full-term pregnancy, premature birth, ectopic pregnancy or abortion. Although GTN is highly sensitive to the chemotherapy, the treatment after chemotherapy drug resistance is the major factordisturbing the treatment of GTN. Studies have shown that in GTN, the incidence of chemotherapy drug resistance in low-risk and high-risk patients is 10% ~20% and 20% ~30%, respectively^[1]. Therefore, the authors in this paper will review the pathogenesis and treatment of the drug-resistant, in order to have a comprehensive and in-depth understanding of GTN, and provide new ideas for the selection of chemotherapy drug-resistant GTN treatment.

Keywords: gestational trophoblastic neoplasm(GTN); chemotherapy; drug resistance

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