WANG Qiannan^a, Ll Yulan^b, MÃ Gang^a, Ll Dayu^a, CAO Deping^a, CHEN Gen^ac( a.College of Basie Medicine , b.College of Clinical Medicine, e.Key Experiment of Pathogen Biology ,Guilin Medical University, Guilin 541199,China)

Abstract lntestinal flora is colonised in the gastrointestinal tract, where it forms a natural protectivebarrier. With age, the intestinal fora is alfected by external faetors such as high salt or high fat diet, longterm medication, bad habits, The composition and abundance of the intestinal flora change, and theharmful flora inerease , which causes disorders in the body's endocrine , immune , metabolism and nerves.and induces pathological aging. The change of intestinal flora is one of the important mechanisms that causepathological aging.Among them,Proteus,Escherichia, Salmonella and other harmful bacteria.lipopolysaccharide, and metabolite trimethlamine aetivate the infammatory signaling pathways such asToll-like receptor 4, NF-kB, C/EBPB/AEP, and eause the production of inlammatory faetors such asNLRP3, ll-6, lL-1β, leading to the occurrence of aging-related diseases, such as Alzheimer's disease.

heart failure, hepatitis, renal failure and chronie obstruetive lung disease. This review summarizes themechanisms of intestinal flora in the development of aging and provides new ideas for the study of usingintestinal fora as a target for the treatment of aging-related diseases.

Keywords:intestinal flora: aging; Alzheimer's disease ; heart failure

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