YIN Kai ^1,2,3② , QIN Jinfeng ^1,2,3

(1.Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin 541199; 2.GuangxiKey Laboratory of Glycolipid Metabolism Diseases, Guilin 541199; 3. Dept. of General Practice, the Fifth Affiliated Hospital of Southern Medical University, Guangzhou 510920, China)

Abstract Epigenetic transcriptional regulation refers to the way that genes are involved in post-transcriptional regulation through reversible chemical modification without changing RNA sequence, which plays an important role in a variety of diseases and pathophysiological processes. Glucose and lipids are the most important energy sources of the human body, and their endogenous metabolism and expression levels are precisely regulated by the body. Abnormal regulation of glucose and lipids is closely related to the occurrence and development of a variety of metabolic diseases. Recent studies have found that epigenetic transcriptional modifications such as N 6 -methyladenosine (m 6 A), 5-meth-cytidine (m 5 C), are involoved in the regulation process of glucose and lipid metabolism by changing the RNA secondary structure, splicing, degradation and stability of key factors. This article mainly reviews the research progress of epigenetic transcriptional regulation involved in glucose and lipid metabolism and related diseases in recent years, so as to provide new ideas for the prevention and treatment of metabolic diseases.

Keywords: epitranscriptomics; N 6 -methyladenosine; glycometabolism; lipid metabolism; intestinal flora

DOI:10.19296/ j.cnki.1008-2409.2023-01-001

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