HAN Si ^①

(Pediatrics Ward I, the First People′s Hospital of Pingdingshan, Pingdingshan 467000, China)

Abstract Objective: To analyze the clinical efficacy of gamma globulin combined with budesonide in the treatment of neonatal pneumonia. Methods:146 cases of neonates with pneumonia were randomized into the conventional group and combination group, each with 73 cases. The conventional group adopted treatment with budesonide, while the combination group were treated with gamma globulin plus budesonide. The treatment effect hospital length of stay, time for the dinical sympton reduction, pulmonary function, inflammatory factors, immune function and incidence of adverse reactions were compared between both groups. Results: After treatment, the total effective rate of the combination group was 95.89 % , higher than 84.93 % of the conventional group, and the disappearance time of lung rales, shortness of breath, perioral cyanosis and hospital stay were shorter than that of the conventional group, the differences were statistically significant (P<0.05); FEV 1 , FVC and PEF levels were all higher in the combination group than in the conventional group ( P < 0.05); ( high mobility group box 1, HMGB1 ), ( matrix metalloproteinase-9,MMP-9), soluble triggering receptor expressed on myeloid cell-1(sTREM-1), high- sensitivity C-reactive protein (hs-CRP) levels were lower in the combined group than in the conventional group(P < 0.05), while CD3 + cells, CD4 + cells, IgG, IgM and IgA levels were all higher in the combination group than in the conventional group (P<0.05). There were no statistical differences of the occurrence of adverse reactions between both groups (P>0.05). Conclusion: Gamma globulin combined with budesonide are able to improve the neonatal immune function and pulmonary function in neonates.

Keywords: gamma globulin; budesonide; neonatal pneumonia; high mobility group box 1; matrix metalloproteinase-9

DOI:10.19296/ j.cnki.1008-2409.2023-01-010

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