HAN Lele

( Department of Emergency, the Affiliated Hospital of Traditional Chinese Medicine of Nanyang Medical College, Nanyang 473000, China)

Abstract Objective To observe the effects of different medication regimens of naloxone on emergency treatment of alcoholism patients and its impact on physical signs and oxygenation index. Methods 112 patients with acute alcoholism were selected and randomly divided into two groups, with 56 cases in each group. Group A were received intravenous injection of 0.8 mg naloxone, administered 12 consecutive times with a 15 min interval between each administration. Group B were infused with 3. 2 mg of naloxone and 250 mL of 0.9% sodium chloride solution intravenously every hour, and administered continuously for 3 h. The treatment efficacy and safety were compared between two groups. Results The levels of β-EP, reduced glutathione ( GSH) , malondialdehyde ( MDA) , and cortisol ( COR) after treatment in Group B after 1, 2 and 3 h of medication were lower than those in Group A, showing a statistically significant difference ( P<0.05) . During the treatment period, the recovery time of consciousness, autonomous standing, language expression, and blood pressure in Group B were lower than those in Group A ( P<0.05) . After treatment, the incidence of drug-related adverse reactions in Group B was lower than that in Group A ( P < 0. 05) .Conclusion Continuous intravenous infusion of naloxone can rapidly improve the condition β-EP levels and reduce oxidative stress damage, which are beneficial for accelerating patient recovery, promoting clinical features and oxygenation index recovery, and reducing the risk of drug-related adverse reactions.

Keywords: alcohol poisoning; naloxone; oxygenation index; drug safety

DOI:10.19296/j.cnki.1008-2409.2024-03-013

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