YOU Qinzhang, QIU Bowen, WU Weibao

( Department of Interventional, the Second Hospital of Longyan, Longyan 

364000, China)

Abstract Objective To investigate the clinical efficacy of transcatheter arterial chemoembolization ( TACE) combined with iodine-125 particles in the treatment of multicentric hepatocellular carcinoma. Methods 60 patients with multicenter liver cancer were selected and randomly divided into two groups. The control group were treated with TACE, while the observation group were treated with TACE and iodine-125 particles. The clinical efficacy, alpha fetoprotein ( AFP ) , and liver function indicators were compared between two groups. Results Before treatment, there was no statistically significant difference in each indicator between two groups ( P>0.05) . After treatment, the effective rate in the observation group was higher than that in the control group, and the levels of AFP, alanine aminotransferase ( ALT) , aspartate aminotransferase ( AST) , and total bilirubin ( TBIL) were all lower in the observation group than those in the control group, showing a statistically significant difference ( P < 0. 05) . Conclusion TACE combined with iodine-125 particles can effectively improve liver function indicators in the treatment of multicentric hepatocellular carcinoma, and has a good clinical therapeutic effect.

Keywords: transcatheter arterial chemoembolization; iodine-125 particles; multicentric hepatocellular carcinoma; clinical efficacy; liver function

DOI:10.19296/j.cnki.1008-2409.2024-03-029

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