JIN Ningchao1, HU Qingqing2, YANG Shuangjie2
( 1.Department of Pediatrics, the First People's Hospital of Xiangfu District, Kaifeng 475100.China:2.Department of Pediatrics, Kaifeng Children's Hospital,
Kaifeng 475100.China)
Abstract Objective To investigate the clinical efficacy of the combination of recombinant human interferon α2b and acyclovir in the children with herpetic angina ( HA ) and its application value. Methods 108 children with HAwere retrospectively selected from January 2022 to December 2022 and divided into monotherapy group (n=54) andcombination group (n =54 ) according to different treatment. Methods The patients in the monotherapy group weretreated with acyclovir, and the patients in the combination group were treated with recombinant human interferon α2b combined with aeyclovir. The total effective rate, clinical symptoms disappearance time, adverse reactions.myocardial injury , inflammatory factor and immune funetion levels before and after treatment were compared between the monotherapy group and combination group. Results The total elfective rate in the combination group was 96.30% , which was higher than 85.19 % in the monotherapy group, showing a statistically significant difference ( P<0.05). After trentment for 7 d, the serum myocardial injury index, inflammatory factor level and CD3+ in thecombination group were lower than those in the monotherapy group, while immunoglobulin A ( IgA ), immunoglobulinG( IgG) , immunoglobulin M ( IgM ) and CD4+ in the combination group were higher than those in the monotherapygroup ( P<0.05 ). The incidenee of adverse reactions in the combination group was 9.26%. which was no statisticallsignificant compared with 5.56% in the monotherapy group ( P>0.05 ). Conclusion Recombinant human interferon α2b combined with acyclovir is ellective therapy in children with HA, which accelerates the process ofrehabilitation , alleviates elfectively the clinical symptoms , improves the myocardial injury , inhibits the inammatoryresponse , and enhances the immune function.
Keywords : herpetic angina ; recombinant human interferon α2b; acyclovir; inflammatory factors ; myocardial injury
DOI:10.19296/j.cnki.1008-2409.2024-04-028
PDF download:click to download
